It is housed in the cloister and convent premises of the Santa Maria della Verità complex, which was founded in the 12th century. Its collections include pieces from the 15th to the 19th century, ancient and medieval inscriptions, examples of numismatics, an archaeological section and two works once housed in the Church of the Almadiani.

Of great importance is the set of 18th century apothecary ceramics from the Ospedale Grande degli Infermi.